About N Butyl Lithium
Product: N-Butyl Lithium 2.5M in Hexane / 1.6M in Hexane
Cas.No:109-72-8
Molecular Weight: 64.06
Density 0.693 g/mL at 25 deg C
concentration 2.5 M in hexanes, Cyclo hexane,
Analysis: sec-Butanol Titration
Essential Reactivity for Precision SynthesisN-Butyl Lithiums profound reactivity enables complex deprotonation, metalation, and polymerization processes that are crucial in advanced chemical manufacturing. Its strong nucleophilicity and basicity make it a preferred reagent for laboratory and industrial settings, helping produce high-value pharmaceutical intermediates and specialty chemicals with exceptional selectivity and efficiency.
Safe Handling and StorageDue to its pyrophoric nature, n-butyl lithium is handled and stored exclusively under an inert atmosphere, typically nitrogen or argon. Proper personal protective equipmentgloves, goggles, lab coatsare mandatory to prevent accidental ignition or hazardous reactions. The liquid is packed in sealed, inert gas-filled bottles or drums, and must be kept away from moisture and air to maintain stability and safety.
Versatile Applications Across IndustriesN-Butyl Lithium plays an indispensable role in organic synthesis, from academic research to industrial-scale production. Its robust performance as a strong base and initiator supports the development of pharmaceuticals, advanced polymers, and specialty compounds, ensuring efficiency and reliability in processes that demand precise and controlled reactivity.
FAQs of N Butyl Lithium:
Q: How should n-butyl lithium be safely handled and stored?
A: N-Butyl Lithium must always be handled in a dry, inert atmosphere (such as nitrogen or argon) to avoid dangerous reactions with air or moisture. It should be stored tightly sealed in its original packaging, away from any sources of heat, moisture, or open flame. Always use proper PPE, including gloves, eye protection, and lab coats.
Q: What is the typical usage of n-butyl lithium in laboratories and industry?
A: N-Butyl Lithium is primarily used as a strong base and nucleophile in organic synthesis, facilitating deprotonation, metalation, and polymerization reactions. It is essential for the preparation of pharmaceutical intermediates, specialty chemicals, and in organometallic laboratory research.
Q: When is n-butyl lithium most beneficial in chemical processes?
A: This reagent is particularly valuable when high selectivity and reactivity are required, such as during the initiation of polymerizations, synthesis of organometallic compounds, or precise deprotonation of sensitive substrates. Its effectiveness greatly benefits laboratories and industries focusing on advanced or custom chemical synthesis.
Q: Where does n-butyl lithium find its main applications?
A: The compound is widely used in research laboratories, pharmaceutical manufacturing, specialty chemical production, and polymer industries. It is distributed and supplied across India and often handled by trained chemists or technicians in controlled environments.
Q: What is the process for manufacturing n-butyl lithium?
A: N-butyl lithium is manufactured by reacting butyl chloride with lithium metal in a hydrocarbon solvent, such as hexane or heptane. This process is carefully controlled under anhydrous, inert conditions to prevent side reactions and ensure product purity.
Q: How is n-butyl lithium disposed of safely after use?
A: Disposal requires neutralization by cautious and controlled methods, strictly following local, state, and federal hazardous waste regulations. It should never be poured down the drain or exposed to air or water, and disposal is best conducted by qualified personnel in a licensed facility.